Miguel Díaz-Canel told crowds in Havana the US is trying to destroy Cuba’s political system.
He said the US seeks complete control over the nation.
Díaz-Canel branded American policies a type of political genocide during July 26 events.
He stressed this is a danger to Cuba’s sovereignty.
Raúl Castro did not attend from the main rally.
Tensions stay high as a result of sanctions and US political pressure.